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Aging21, 245-255. Howieson, D. , Holm, L. , Kaye, J. , Oken, B. , and Howieson, J. (1993). Neurologic function in the optimally healthy oldest old: Neuropsychological evaluation. Neur0/ogy43, 1882-1886. , Urakami, ~ , and Shoji, M. (1999). Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. Neurosci. Lett. 277, 65-67. Hyman, B. , and Trojanowski, J. Q. (1997). J. Neuropathol. Exp. NeuroL 56, 1095-1097. , Guijarro,J. , Gonzalo, L. , and de Lacalle, S.

And Pfefferbaum, A. (1995). Longitudinal volumetric computed tomographic analysis of regional brain changes in normal aging and Alzheimer's disease. Arch. NeuroL 52, 392402. Shefer, V. E (1973). Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's disease. Zhurnal Nevropatologii i Psikhiatrii imeni S. S. Korsakova 1972;72:1024-1029. (Translated in Neurosci. Behav. Physiol. , Smith, M. , and Friedland, R. P.

N. (2000). Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: Power calculations and estimates of sample size to detect treatment effects. Arch. Neurol. 57, 339-344. Fox, N. , Warrington, E. , Hartikainen, E, Kennedy, A. , Stevens,J. , and Rossor, M. N. (1996). Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. Brain 119, 2001-2007. , Palmer, A. , and Wilcock, G. K. (1999). The cholinergic hypothesis of Alzheimer's disease: A review of progress.

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