New PDF release: Amyloid and Related Disorders: Surgical Pathology and

By Per Westermark M.D., Ph.D. (auth.), Maria M. Picken MD, PhD, FASN, Ahmet Dogan, M.D., Ph.D., Guillermo A. Herrera, M.D. (eds.)

ISBN-10: 1607613883

ISBN-13: 9781607613886

Abnormal proteins are identified to be linked to quite a few pathologies. so much significantly, those comprise amyloidoses, monoclonal protein deposits linked to plasma phone dyscrasia/multiple myeloma, cryoglobulins and numerous similar equipped and non-organized deposits.

Amyloid and similar Disorders provides an summary of the main

recent advancements during this sector together with medical presentation, etiology, pathogenesis, and differential analysis. the explanation for varied cures, together with transplantation, is mentioned and tissue prognosis (its pitfalls and techniques for keeping off them) and laboratory aid are incorporated. The involvement of all significant organ platforms together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central worried process, gentle tissue and bone marrow pathology is roofed. This technique offers a unifying proposal of those pathologic tactics, that have systemic involvement, and that have, hitherto, no longer been universally liked. know-how of those illnesses between a much wider viewers of pathologists may well raise the speed in their prognosis in addition to that of past analysis. This quantity could be worthy to really expert and common pathologists in addition to cytopathologists; different doctors can also make the most of this concise replace at the systemic amyloidoses.

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Extra resources for Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Sample text

Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis. Blood. 2007;110:787–8. 2 Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis 190. Merlini G, Ascari E, Amboldi N, et al. Interaction of the anthracycline 4 -iodo-4 -deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis. Proc Natl Acad Sci USA. 1995;92:2959–63. 191. Gianni L, Bellotti V, Gianni AM, et al. New drug therapy of amyloidoses: resorption of AL-type deposits with 4 -iodo-4 -deoxydoxorubicin.

2008;19 Suppl 4:iv63–6. Gertz MA, Lacy MQ, Dispenzieri A. Immunoglobulin light chain amyloidosis and the kidney. Kidney Int. 2002;61:1–9. Gertz MA, Leung N, Lacy MQ, et al. Clinical outcome of immunoglobulin light chain amyloidosis affecting the kidney. Nephrol Dial Transplant. 2009;24:3132–7. Bergesio F, Ciciani AM, Manganaro M, et al. Renal involvement in systemic amyloidosis: an Italian collaborative study on survival and renal outcome. Nephrol Dial Transplant. 2008;23:941–51. Leung N, Dispenzieri A, Lacy MQ, et al.

Evidence that amyloidogenic light chains undergo antigendriven selection. Blood. 1998;91:2948–54. 114. Abraham RS, Geyer SM, Ramirez-Alvarado M, et al. Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL). J Clin Immunol. 2004;24:340–53. 115. Abraham RS, Manske MK, Zuckerman NS, et al. Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis. J Clin Immunol.

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Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations by Per Westermark M.D., Ph.D. (auth.), Maria M. Picken MD, PhD, FASN, Ahmet Dogan, M.D., Ph.D., Guillermo A. Herrera, M.D. (eds.)

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