Get Anatomy of a Scientific Discovery: The Race to Find the PDF

By Jeff Goldberg

ISBN-10: 1626361932

ISBN-13: 9781626361935

In overdue 1973, scientists John Hughes and Hans Kosterlitz spent the vast majority of their time in an underfunded, vague, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo came across a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they might isolate this chemical in people, probably they can give you the option to aid the area start to heal itself. Hughes and Kosterlitz’s study could necessarily make them observe endorphins, the body’s personal common morphine and the chemical that makes it attainable to think either soreness and pleasure.

Announcing their findings to the medical global thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been swiftly interpreting the human mind and its endorphins. In many years’ time, they might use the team’s preliminary study to hyperlink endorphins to drug habit, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems akin to melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives earlier than, in the course of, and after their historical and clinical leap forward. He additionally takes a glance on the greater photograph, revealing the brutal pageant among drug businesses to discover the way to profit from this enormous discovery.

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Sample text

Texas oilmen roamed the streets in ten-gallon hats and cowboy boots, and the young men who worked the rigs came into town on the weekends like western movie extras, their pockets stuffed with cash, to drink and brawl themselves into oblivion. Oil was bringing prosperity and development to Aberdeen; new office buildings and shops were springing up among the grim granite edifices. All the buildings in and around Aberdeen were made of granite mined from a nearby quarry—the building code of the “granite city” is still very strict in this regard.

Despite the cleverness of Goldstein’s grind and bind technique, his own results had been disappointing so far: Only about 2 percent of the radioactive material remained in the beakers. “It was like picking up a very weak signal on a shortwave radio during a static storm,” he recalls. While that was not nearly good enough to prove the existence of opiate receptors, “stereospecificity” became the litmus test for detecting them, and a number of other researchers in the field began struggling to make Goldstein’s technique work.

Goldstein’s analytical mind worried the Aberdeen scientists. A striking figure, tall and lanky with a Lincoln-esque beard, Goldstein was, in one colleague’s assessment, “a kind of Renaissance man,” who flew his own plane and, in addition to his classic textbook Principles of Drug Action, had authored a definitive pamphlet on instrument flying. His father was Rabbi Israel Goldstein, a founder of Brandeis University, the religious leader of Manhattan’s largest conservative Jewish congregation, and a man who headed virtually every major Jewish organization at one time or another during his long career.

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Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg

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