By S.R. Pandi-Perumal
Covers scientific and pharmacological remedies for numerous sleep problems, corresponding to insomnia, sleep apnea, narcolepsy, stressed legs syndrome, and periodic limb circulate syndrome. This quantity addresses using sleep medicinal drugs in youngsters, teens, and within the aged, and in addition deals an outline of hypnotic medications.
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Woch G, Davies RO, Pack AI, Kubin L (1996) Behaviour of raphe cells projecting to the dorsomedial medulla during carbachol-induced atonia in the cat. J Physiol 490 (Pt 3): 745–758 32. Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165–229 33. Jelev A, Sood S, Liu H, Nolan P, Horner RL (2001) Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol 532(Pt 2): 467–481 34.
Neuropharmacology of obstructive sleep apnea and central apnea 29 Physostigmine The cholinesterase inhibitor physostigmine has been investigated in a small blinded, placebo-controlled study of moderate to severe OSA patients, and via steady-state intravenous infusion been shown to modestly decrease the overall AHI and severity of oxygen desaturation, predominantly in REM compared with NREM sleep . The exact mechanism of the beneﬁcial action of physostigmine in sleep apnea is not clear. Novel therapy A novel approach to the treatment of OSA has used the intrapharyngeal application of an exogenous surfactant preparation, which lowers the surface tension of upper airway lining liquid and thereby reduces upper airway opening and closing pressures.
Smith I, Lasserson T, Wright J (2002) Drug treatments for obstructive sleep apnoea. Cochrane Database Syst Rev 2: CD003002 71. Grunstein RR, Hedner J, L Grote (2001) Treatment options for sleep apnoea. Drugs 61: 237–251 72. Cook WR, Benich JJ, Wooten SA (1989) Indices of severity of obstructive sleep apnea syndrome do not change during medroxyprogesterone acetate therapy. Chest 96: 262– 266 73. Wesstrom J, Ulfberg J, Nilsson S (2005) Sleep apnea and hormone replacement therapy: a pilot study and a literature review.
Clinical pharmacology of sleep by S.R. Pandi-Perumal